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Abstract：
Molecularly imprinted polymers (MIPs) are specific crosslinked polymers that exhibit binding sites for template molecules. MIPs have been developed in various application areas of biology and chemistry; however, MIPs have some problems, including an irregular material shape. In recent years, studies have been conducted to overcome this drawback, with the synthesis of uniform microsphere MIPs or molecularly imprinted microspheres (MIMs). The polymer microsphere is limited to a minimum size of 5 nm and a molecular weight of 10,000 Da. This review describes the methods used to produce MIMs, such as precipitation polymerisation, controlled/\'Living\' radical precipitation polymerisation (CRPP), Pickering emulsion polymerisation and suspension polymerisation. In addition, some green chemistry aspects and future perspectives will also be given.
摘要：
分子印迹聚合物(MIP)是显示模板分子的结合位点的特异性交联聚合物。MIP已在生物学和化学的各种应用领域中开发；但是，MIP有一些问题，包括不规则的材料形状。近年来,已经进行了研究来克服这一缺点，合成均匀微球MIP或分子印迹微球(MIMs)。聚合物微球被限制为5nm的最小尺寸和10,000Da的分子量。这篇综述描述了用于生产MIMs的方法，如沉淀聚合，受控/'活自由基沉淀聚合(CRPP)，Pickering乳液聚合和悬浮聚合。此外,还将给出一些绿色化学方面的内容和未来的前景。
