关键词: infectious diseases pharmacology and therapeutics renal medicine renal transplantation

Mesh : Betacoronavirus / isolation & purification COVID-19 Coronavirus Infections / diagnosis drug therapy virology Female Glucocorticoids / therapeutic use Hospitalization Humans Immunosuppression Therapy / adverse effects Immunosuppressive Agents / therapeutic use Kidney Transplantation / adverse effects Middle Aged Pandemics Pneumonia, Viral / diagnosis drug therapy virology Prednisolone / therapeutic use SARS-CoV-2 Tacrolimus / therapeutic use Transplant Recipients / statistics & numerical data Treatment Outcome

来  源:   DOI:10.1136/bcr-2020-237427   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Kidney transplant recipients have been reported at a particularly high risk of severe COVID-19 illness due to chronic immunosuppression and coexisting conditions. Yet, here we describe a remarkably mild case of COVID-19 in a 62-year-old female who had a kidney transplantation 10 years earlier due to autosomal dominant polycystic kidney disease. The patient was admitted for 1 day; immunosuppressive therapy with tacrolimus and low-dose prednisolone was continued; and the patient recovered successfully without the use of antiviral agents or oxygen therapy. The case demonstrates that kidney transplant recipients are not necessarily severely affected by COVID-19. Withdrawal of immunosuppressive therapy could be associated with poorer outcomes and should not be implemented thoughtlessly.
摘要:
据报道,由于慢性免疫抑制和共存疾病,肾移植受者患严重COVID-19疾病的风险特别高。然而,在这里,我们描述了一例62岁女性的COVID-19病例,该女性10年前因常染色体显性遗传性多囊肾病进行了肾脏移植。患者入院1天;继续他克莫司和低剂量泼尼松龙的免疫抑制治疗;患者在不使用抗病毒药物或氧气治疗的情况下成功康复。该病例表明,肾移植受者不一定受到COVID-19的严重影响。取消免疫抑制治疗可能与较差的预后有关,不应轻思地实施。
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