Abstract：
Previous studies have evaluated associations of XPG rs17655G>C and XPF rs1799801T>C polymorphisms with a risk of cutaneous malignant melanoma (CMM). However, their results thus remained inconsistent or even contradictory. Thus, the aim of this meta-analysis was to evaluate association of XPG rs17655G>C and XPF rs1799801T>C polymorphism with a risk of CMM.
A comprehensive literature search was performed on PubMed, Web of Science, Scopus, SciELO and CNKI databases up to October 15, 2019 to identify relevant studies. Moreover, a case-control study was conducted to evaluate association of XPF rs1799801T>C with CMM risk in the Iranian population. The odds ratio (OR) and 95% confidence interval (CI) values were used to estimate the strength of the associations.
Total of 12 studies including 9 studies with 5,362 cases and 7,195 controls on XPG rs17655G>C and 3 studies with 803 CMM cases and 737 controls on XPF rs1799801T>C were selected. Pooled data revealed that XPF rs1799801T>C polymorphism was significantly associated with an increased risk of CMM under the heterozygote model (CT vs. TT: OR = 1.313; 95% CI 1.062-1.624; P = 0.012). However, XPG rs17655G>C polymorphism was not significantly associated with the risk of CMM in the overall population and by ethnicity. The subgroup analysis showed a significant association between XPG rs17655G>C polymorphism and CMM in polymerase chain reaction-based restriction fragments length polymorphism (PCR-RFLP) group of studies.
This meta-analysis result revealed that XPF rs1799801T>C polymorphism may be a risk factor for developing of CMM. However, our pooled data inconsistence with the previous meta-analyses revealed that XPG rs17655G>C polymorphism was not associated with the risk of CMM.
A comprehensive literature search was performed on PubMed, Web of Science, Scopus, SciELO and CNKI databases up to October 15, 2019 to identify relevant studies. Moreover, a case-control study was conducted to evaluate association of XPF rs1799801T>C with CMM risk in the Iranian population. The odds ratio (OR) and 95% confidence interval (CI) values were used to estimate the strength of the associations.
Total of 12 studies including 9 studies with 5,362 cases and 7,195 controls on XPG rs17655G>C and 3 studies with 803 CMM cases and 737 controls on XPF rs1799801T>C were selected. Pooled data revealed that XPF rs1799801T>C polymorphism was significantly associated with an increased risk of CMM under the heterozygote model (CT vs. TT: OR = 1.313; 95% CI 1.062-1.624; P = 0.012). However, XPG rs17655G>C polymorphism was not significantly associated with the risk of CMM in the overall population and by ethnicity. The subgroup analysis showed a significant association between XPG rs17655G>C polymorphism and CMM in polymerase chain reaction-based restriction fragments length polymorphism (PCR-RFLP) group of studies.
This meta-analysis result revealed that XPF rs1799801T>C polymorphism may be a risk factor for developing of CMM. However, our pooled data inconsistence with the previous meta-analyses revealed that XPG rs17655G>C polymorphism was not associated with the risk of CMM.
摘要：
先前的研究已经评估了XPGrs17655G>C和XPFrs1799801T>C多态性与皮肤恶性黑色素瘤（CMM）风险的关联。然而,因此，他们的结果仍然不一致甚至矛盾。因此，本荟萃分析的目的是评估XPGrs17655G>C和XPFrs1799801T>C多态性与CMM风险的关联.
在PubMed上进行了全面的文献检索，WebofScience,Scopus,截至2019年10月15日的SciELO和CNKI数据库，以确定相关研究。此外，在伊朗人群中进行了一项病例对照研究,以评估XPFrs1799801T>C与CMM风险的相关性.比值比（OR）和95％置信区间（CI）值用于估计关联的强度。
总共12项研究，其中9项研究涉及5,362例病例和7,195例对照XPGrs17655G>C，3项研究涉及803例CMM病例和737例对照XPFrs1799801T>C。汇总数据显示，在杂合子模型下，XPFrs1799801T＆gt;C多态性与CMM风险增加显着相关（CT与TT：OR=1.313；95%CI1.062-1.624；P=0.012)。然而,XPGrs17655G>C多态性与总体人群和种族中的CMM风险没有显着相关。亚组分析显示，在基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）研究组中，XPGrs17655G＆gt;C多态性与CMM之间存在显着关联。
这项荟萃分析结果表明，XPFrs1799801T>C多态性可能是CMM发生的危险因素。然而,我们的汇总数据与之前的荟萃分析不一致,显示XPGrs17655G>C多态性与CMM风险无关.
在PubMed上进行了全面的文献检索，WebofScience,Scopus,截至2019年10月15日的SciELO和CNKI数据库，以确定相关研究。此外，在伊朗人群中进行了一项病例对照研究,以评估XPFrs1799801T>C与CMM风险的相关性.比值比（OR）和95％置信区间（CI）值用于估计关联的强度。
总共12项研究，其中9项研究涉及5,362例病例和7,195例对照XPGrs17655G>C，3项研究涉及803例CMM病例和737例对照XPFrs1799801T>C。汇总数据显示，在杂合子模型下，XPFrs1799801T＆gt;C多态性与CMM风险增加显着相关（CT与TT：OR=1.313；95%CI1.062-1.624；P=0.012)。然而,XPGrs17655G>C多态性与总体人群和种族中的CMM风险没有显着相关。亚组分析显示，在基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）研究组中，XPGrs17655G＆gt;C多态性与CMM之间存在显着关联。
这项荟萃分析结果表明，XPFrs1799801T>C多态性可能是CMM发生的危险因素。然而,我们的汇总数据与之前的荟萃分析不一致,显示XPGrs17655G>C多态性与CMM风险无关.
