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Abstract：
11C-UCB-J ((R)-1-((3-(11C-methyl-11C)pyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-one) is a PET tracer for synaptic vesicle glycoprotein 2A, which may be a marker of synaptic density. To simplify the scan protocol, SUV ratios (SUVRs) were compared with model-based nondisplaceable binding potential (BPND) to select the optimal time window in healthy and neuropsychiatric subjects. Methods: In total, 141 scans were acquired for 90 min. Arterial blood sampling and metabolite analysis were conducted. SUVR-1 (centrum semiovale reference region) was computed for six 30-min windows and compared with 1-tissue-compartment model BPND Simulations were performed to assess the time dependency of SUVR-1. Results: Greater correlation and less bias were observed for SUVR-1 at later time windows for all subjects. Simulations showed that the agreement between SUVR-1 and BPND is time-dependent. Conclusion: The 60- to 90-min period provided the best match between SUVR-1 and BPND (-1% ± 7%); thus, a short scan is sufficient for accurate quantification of 11C-UCB-J-specific binding.
摘要：
11C-UCB-J（（R）-1-（（3-（11C-甲基-11C）吡啶-4-基）甲基）-4-（3,4,5-三氟苯基）吡咯烷-2-酮）是突触小泡糖蛋白2A的PET示踪剂，这可能是突触密度的标志。为了简化扫描协议，将SUV比率（SUVR）与基于模型的非位移结合电位（BPND）进行比较，以选择健康和神经精神受试者的最佳时间窗口。方法：总计，在90分钟内获得141次扫描。进行了动脉血采样和代谢物分析。在六个30分钟的窗口中计算SUVR-1（半卵中心参考区域），并与1-组织室模型BPND进行比较。进行模拟以评估SUVR-1的时间依赖性。结果：对于所有受试者，在较晚的时间窗口观察到SUVR-1更大的相关性和更少的偏倚。仿真结果表明，SUVR-1和BPND之间的协议是时间依赖性的。结论：60至90分钟的时间段提供了SUVR-1和BPND之间的最佳匹配（-1％±7％）；因此，短扫描足以准确定量11C-UCB-J特异性结合。
