PDF(Sci-hub)
Abstract：
With the development of biotherapy, biomacromolecular drugs have gained tremendous attention recently, especially in drug development field due to the sophisticated functions in vivo. Over the past few years, a motley variety of drug delivery strategies have been developed for biomacromolecular drugs to overcome the difficulties in the druggability, e.g., the instability and easily restricted by physiologic barriers. The application of novel delivery systems to deliver biomacromolecular drugs can usually prolong the half-life, increase the bioavailability, or improve patient compliance, which greatly improves the efficacy and potentiality for clinical use of biomacromolecular drugs. In this review, recent studies regarding the drug delivery strategies for macromolecular drugs in cancer therapy are summarized, mainly drawing on the development over the last five years.
摘要：
随着生物治疗的发展,生物大分子药物最近获得了极大的关注,特别是在药物开发领域由于复杂的体内功能。在过去的几年里，已经开发了各种各样的生物大分子药物给药策略，以克服成药的困难，例如，不稳定，容易受到生理障碍的限制。应用新型递送系统递送生物大分子药物通常可以延长半衰期,增加生物利用度，或提高患者的依从性，大大提高了生物大分子药物的疗效和临床应用潜力。在这次审查中,总结了近年来关于高分子药物在癌症治疗中的药物递送策略的研究，主要是借鉴过去五年的发展。
