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Abstract：
Condylar hyperplasia is known to result in facial asymmetries and constitutes a well-recognized group of unilateral mandibular enlargements. Condylar hyperplasia has been sub-classified into hemimandibular hyperplasia and hemimandibular elongation. A much rarer disorder, hemifacial hyperplasia (or hemifacial hypertrophy) is a congenital malformation characterized by prominent unilateral overdevelopment of the hard and soft tissues of the face. The affected side grows at a faster rate than the non-affected side, creating a marked asymmetry that potentially involves the skeleton and teeth, as well as all components of the associated soft tissues. Hemifacial hyperplasia is usually identified at birth and progresses towards puberty, but is not thought to alter throughout the lifetime of affected individuals. A case series of five patients clinically diagnosed with hemifacial hyperplasia is presented, with the aim of reviewing the clinical features, discussing their individual surgical management, and summarizing the more recent identification of possible genetic mutations that may be responsible for hemifacial hyperplasia and related overgrowth disorders. It is speculated that depending on the genetic factors, the disorder may be progressive in specific cases.
摘要：
众所周知，髁突增生会导致面部不对称，并构成公认的单侧下颌扩大组。髁突增生已分为半下颌增生和半下颌伸长。一种罕见得多的疾病，半颜面增生（或半颜面肥大）是一种先天性畸形，其特征是面部硬组织和软组织明显的单侧过度发育。受影响侧的生长速度比非受影响侧的生长速度快,造成明显的不对称，可能涉及骨骼和牙齿，以及相关软组织的所有成分。面部增生通常在出生时被发现，并进展到青春期，但被认为不会在受影响个体的整个一生中发生变化。介绍了5例临床诊断为半颜面增生的患者，为了回顾临床特征，讨论他们的个人手术管理，并总结了最近对可能导致半颜面增生和相关过度生长障碍的基因突变的鉴定。据推测，根据遗传因素，在特定情况下，该疾病可能是进行性的。
