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Abstract：
UNASSIGNED: To study the type of bacteria and their antibiotic susceptibility pattern from corneal scrapings of patients with infectious keratitis presenting with concurrent nasolacrimal duct obstruction.
UNASSIGNED: A retrospective analysis was carried out of patients with microbial keratitis and co-existing nasolacrimal duct obstruction during a 5-year period (January 2012 to December 2016). Antibiotic susceptibility profile data was collected from the microbiology records.
UNASSIGNED: The study included 56 (M:F = 33:23; OD:OS = 34:22) eyes. The mean age of patients was 60.2 ± 12.3 years. Microscopic examination of corneal scrapings showed 52% of gram-positive (n = 29/55) and 2% of multiple (>1; n = 1/55) bacteria. Streptococcus pneumoniae (32%, n = 18/56), coagulase-negative Staphylococcus (25%, n = 14/56), and Staphylococcus aureus (11%, n = 6/56) were the most common bacteria. Streptococcus pneumoniae was found to be susceptible to ciprofloxacin (72.2%), ofloxacin (94.4%), gatifloxacin (61.1%), and moxifloxacin (83.3%).
UNASSIGNED: Corneal infection associated with nasolacrimal duct obstruction is commonly caused by gram-positive-bacteria. Irrigation of nasolacrimal duct should be mandatory test in microbial keratitis. The gram-positive bacteria isolated showed maximum susceptibility to vancomycin and cefazolin. Early treatment by surgery and appropriate medical management is recommended for its control.
UNASSIGNED: A retrospective analysis was carried out of patients with microbial keratitis and co-existing nasolacrimal duct obstruction during a 5-year period (January 2012 to December 2016). Antibiotic susceptibility profile data was collected from the microbiology records.
UNASSIGNED: The study included 56 (M:F = 33:23; OD:OS = 34:22) eyes. The mean age of patients was 60.2 ± 12.3 years. Microscopic examination of corneal scrapings showed 52% of gram-positive (n = 29/55) and 2% of multiple (>1; n = 1/55) bacteria. Streptococcus pneumoniae (32%, n = 18/56), coagulase-negative Staphylococcus (25%, n = 14/56), and Staphylococcus aureus (11%, n = 6/56) were the most common bacteria. Streptococcus pneumoniae was found to be susceptible to ciprofloxacin (72.2%), ofloxacin (94.4%), gatifloxacin (61.1%), and moxifloxacin (83.3%).
UNASSIGNED: Corneal infection associated with nasolacrimal duct obstruction is commonly caused by gram-positive-bacteria. Irrigation of nasolacrimal duct should be mandatory test in microbial keratitis. The gram-positive bacteria isolated showed maximum susceptibility to vancomycin and cefazolin. Early treatment by surgery and appropriate medical management is recommended for its control.
摘要：
■从并发鼻泪管阻塞的感染性角膜炎患者的角膜刮片中研究细菌的类型及其抗生素敏感性模式。
■对5年（2012年1月至2016年12月）期间微生物性角膜炎和并存鼻泪管阻塞的患者进行了回顾性分析。从微生物学记录中收集抗生素敏感性概况数据。
■该研究包括56只(M:F=33:23;OD:OS=34:22)眼。患者平均年龄为60.2±12.3岁。角膜刮片的显微镜检查显示52％的革兰氏阳性（n=29/55）和2％的多种（>1；n=1/55）细菌。肺炎链球菌（32%，n=18/56），凝固酶阴性葡萄球菌(25%，n=14/56），和金黄色葡萄球菌(11%，n=6/56）是最常见的细菌。肺炎链球菌对环丙沙星易感(72.2%),氧氟沙星（94.4%），加替沙星（61.1%），和莫西沙星（83.3%）。
■与鼻泪管阻塞相关的角膜感染通常由革兰氏阳性菌引起。冲洗鼻泪管应该是微生物性角膜炎的强制性测试。分离出的革兰氏阳性菌对万古霉素和头孢唑啉的敏感性最大。建议通过手术进行早期治疗和适当的医疗管理来控制。
■对5年（2012年1月至2016年12月）期间微生物性角膜炎和并存鼻泪管阻塞的患者进行了回顾性分析。从微生物学记录中收集抗生素敏感性概况数据。
■该研究包括56只(M:F=33:23;OD:OS=34:22)眼。患者平均年龄为60.2±12.3岁。角膜刮片的显微镜检查显示52％的革兰氏阳性（n=29/55）和2％的多种（>1；n=1/55）细菌。肺炎链球菌（32%，n=18/56），凝固酶阴性葡萄球菌(25%，n=14/56），和金黄色葡萄球菌(11%，n=6/56）是最常见的细菌。肺炎链球菌对环丙沙星易感(72.2%),氧氟沙星（94.4%），加替沙星（61.1%），和莫西沙星（83.3%）。
■与鼻泪管阻塞相关的角膜感染通常由革兰氏阳性菌引起。冲洗鼻泪管应该是微生物性角膜炎的强制性测试。分离出的革兰氏阳性菌对万古霉素和头孢唑啉的敏感性最大。建议通过手术进行早期治疗和适当的医疗管理来控制。
