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Abstract：
Phototherapeutic keratectomy (PTK) with 193-nm excimer laser is a safe and effective procedure for the treatment of superficial corneal pathology. We aimed to review the use of PTK for the treatment of corneal macular dystrophy (MCD).
Case report and literature review.
A 16-year-old boy presented to an ophthalmologist with a 4-year history of reduced vision, glare and photophobia in his left eye. He was diagnosed with corneal macular dystrophy and underwent sequencing of the CHST6 gene. Left excimer PTK with mitomycin C was performed. He remained relapse free until 18 months post procedure when his visual acuity declined and the stroma appeared more \"milky\". He underwent a penetrating keratoplasty in his left eye 24 month following the initial PTK.
Phototherapeutic keratectomy is an effective means of visual restoration in patients with macular corneal dystrophy and may delay penetrating keratoplasty. Patients should be counselled regarding the high risk of recurrence. This is the first reported case of a CHST6 gene positive patient with MCD that was treated with phototherapeutic keratoplasty.
Case report and literature review.
A 16-year-old boy presented to an ophthalmologist with a 4-year history of reduced vision, glare and photophobia in his left eye. He was diagnosed with corneal macular dystrophy and underwent sequencing of the CHST6 gene. Left excimer PTK with mitomycin C was performed. He remained relapse free until 18 months post procedure when his visual acuity declined and the stroma appeared more \"milky\". He underwent a penetrating keratoplasty in his left eye 24 month following the initial PTK.
Phototherapeutic keratectomy is an effective means of visual restoration in patients with macular corneal dystrophy and may delay penetrating keratoplasty. Patients should be counselled regarding the high risk of recurrence. This is the first reported case of a CHST6 gene positive patient with MCD that was treated with phototherapeutic keratoplasty.
摘要：
193nm准分子激光的光疗角膜切除术（PTK）是治疗浅层角膜病理的安全有效方法。我们旨在回顾PTK在治疗角膜黄斑营养不良（MCD）中的应用。
病例报告及文献复习。
一个16岁的男孩出现在眼科医生面前，他有4年的视力下降史，他的左眼眩光和畏光。他被诊断为角膜黄斑营养不良，并接受了CHST6基因测序。用丝裂霉素C进行左准分子PTK。直到术后18个月，他的视力下降，基质看起来更“乳白色”，他一直没有复发。在最初的PTK后24个月，他在左眼接受了穿透性角膜移植术。
光疗性角膜切除术是黄斑角膜营养不良患者视觉恢复的有效手段，可能会延迟穿透性角膜移植术。应就复发的高风险对患者进行咨询。这是第一例报道的患有MCD的CHST6基因阳性患者接受光疗角膜移植术治疗。
病例报告及文献复习。
一个16岁的男孩出现在眼科医生面前，他有4年的视力下降史，他的左眼眩光和畏光。他被诊断为角膜黄斑营养不良，并接受了CHST6基因测序。用丝裂霉素C进行左准分子PTK。直到术后18个月，他的视力下降，基质看起来更“乳白色”，他一直没有复发。在最初的PTK后24个月，他在左眼接受了穿透性角膜移植术。
光疗性角膜切除术是黄斑角膜营养不良患者视觉恢复的有效手段，可能会延迟穿透性角膜移植术。应就复发的高风险对患者进行咨询。这是第一例报道的患有MCD的CHST6基因阳性患者接受光疗角膜移植术治疗。
