UNASSIGNED: For the longitudinal analysis (2004-2019), we compared systolic and diastolic function in 10 Senning patients. For the cross-sectional analysis, we compared the subaortic RV (sRV) of Senning patients with the RV and LV of matched controls and the subpulmonary LV (spLV) of Senning patients with the LV of matched controls.
UNASSIGNED: The longitudinal analysis of sRV function showed a significant decrease in apical peak systolic strain (-17 ± 7% vs -12 ± 4%; p = 0.025) and apical peak systolic strain rate (-1.1 ± 0.3s-1 vs -0.8 ± 0.4s-1; p = 0.012). spLV function showed a significant decrease in peak systolic velocity (mid; p = 0.013 and apex; p = 0.011) and peak systolic strain rate (mid; p = 0.048). The cross-sectional analysis revealed significant lower values for basal, mid and apical peak systolic velocity, peak systolic strain rate, peak systolic strain of the sRV of Senning patients when compared to both LV and RV of matched controls (all p < 0.05).
UNASSIGNED: Our study showed that systolic and diastolic sRV function did not change over a 15-year follow-up period, except in the apical region. There was a decline in spLV systolic function, which may be of clinical value. On the other hand, when compared to age- and gender-matched controls, the sRV of Senning patients exhibits significantly decreased measurements of longitudinal systolic function.
■对于纵向分析(2004-2019),我们比较了10例Senning患者的收缩和舒张功能。对于横截面分析,我们比较了Senning患者的主动脉下RV(sRV)与匹配对照组的RV和LV,以及Senning患者的肺动脉下LV(spLV)与匹配对照组的LV.
■sRV功能的纵向分析表明,根尖收缩峰值应变(-17±7%vs-12±4%;p=0.025)和根尖收缩峰值应变率(-1.1±0.3s-1vs-0.8±0.4s-1;p=0.012)显着降低。spLV功能显示收缩期峰值速度(中;p=0.013和顶点;p=0.011)和收缩期峰值应变率(中;p=0.048)显着降低。横截面分析显示,基础值显著较低,中尖峰值收缩期速度,收缩期应变率峰值,与匹配对照的LV和RV相比,Senning患者的sRV的收缩期峰值应变(均p<0.05)。
■我们的研究表明,在15年的随访期内,sRV的收缩和舒张功能没有变化,除了顶端区域。spLV收缩功能下降,这可能具有临床价值。另一方面,与年龄和性别匹配的对照相比,Senning患者的sRV表现出纵向收缩功能的测量值明显降低。