Lithium and coronaviral infections. A scoping review.

锂是新型武汉 (2019 - nCoV) 冠状病毒的潜在治疗方法吗 ？ 范围审查。

• 发表时间: 2020
• 来源期刊: F1000Res
• DOI: 10.12688/f1000research.22299.2
• PMID: 32518634
• 文章类型: Journal Article
• 作者列表: Nowak JK,Walkowiak J,Nowak JK,Walkowiak J

关键词: 2019-nCoV; Coronaviridae; GSK-3β; Wuhan; antiviral; apoptosis; coronavirus; glycogen synthase kinase 3-beta; lithium; lithium carbonate; lithium orotate; 2019-nCoV; Coronaviridae; GSK-3β; Wuhan; antiviral; apoptosis; coronavirus; glycogen synthase kinase 3-beta; lithium; lithium carbonate; lithium orotate

Mesh: Animals; Betacoronavirus; COVID-19; Cells, Cultured; Chloroquine / therapeutic use; Coronavirus Infections / drug therapy; Humans; Lithium / therapeutic use; Pandemics; Pneumonia, Viral / drug therapy; SARS-CoV-2; Animals; Betacoronavirus; COVID-19; Cells, Cultured; Chloroquine / therapeutic use; Coronavirus Infections / drug therapy; Humans; Lithium / therapeutic use; Pandemics; Pneumonia, Viral / drug therapy; SARS-CoV-2

Abstract

The current rapid spread of the novel coronavirus (SARS-CoV-2) causing coronavirus disease 2019 (COVID-19) calls for a rapid response from the research community. Lithium is widely used to treat bipolar disorder, but has been shown to exhibit antiviral activity. This brief review took a systematic approach to identify six in vitro studies reporting on the influence of lithium on coronaviral infections. We propose mechanistic investigation of the influence of lithium - alone and with chloroquine - on the SARS-CoV-2 infection.

摘要

目前源自武汉的新型冠状病毒（2019-nCoV）的快速传播，中国,呼吁研究界做出快速反应。锂被广泛用于治疗双相情感障碍，但已被证明具有抗病毒活性。这篇简短的评论采用了系统的方法来确定五项报告锂对冠状病毒感染影响的体外研究。我们建议在迫切需要的情况下，锂作为新型武汉冠状病毒（2019-nCoV）的潜在治疗或预防方法进行探索。