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Abstract：
The microenvironment of oral cancer is highly dynamic and has been proved to affect tumor progression. Pericytes are blood vessels surrounding cells that have recently gained attention for their roles in vascular and cancer biology. The objective of the present study was to survey the scientific literature for conclusive evidence about whether pericytes are part of blood vessels in oral squamous cell carcinoma (OSCC) and their roles in the tumor microenvironment and clinical outcomes. A systematic electronic search was undertaken in Medline Ovid, PubMed, Web of Science, and Scopus. Eligibility criteria were: publications adopting in vivo models of OSCC that included pericyte detection and assessment by pericyte markers (e.g., α-smooth muscle actin, neuron-glial antigen 2 and platelet-derived growth factor receptor-β). The search yielded seven eligible studies (from 2008 to 2018). The markers most commonly used for pericyte detection were α-smooth muscle actin and neuron-glial antigen 2. The studies reviewed showed the presence of immature vessels exhibiting a reduction of pericyte coverage in OSCC and indicated that anti-cancer therapies could contribute to vessel normalization and pericyte regain. The pericyte population is significantly affected during OSCC development and cancer therapy. While these findings might suggest a role for pericytes in OSCC progression, the limited data available do not allow us to conclude whether they modify the tumor microenvironment and clinical outcome.
摘要：
口腔癌的微环境是高度动态的，并已被证明会影响肿瘤的进展。周细胞是细胞周围的血管，最近因其在血管和癌症生物学中的作用而受到关注。本研究的目的是调查科学文献，以获得有关周细胞是否是口腔鳞状细胞癌（OSCC）血管的一部分及其在肿瘤微环境和临床结局中的作用的确凿证据。在MedlineOvid进行了系统的电子搜索，PubMed,WebofScience,还有Scopus.合格标准是：出版物采用OSCC的体内模型，其中包括周细胞检测和周细胞标记物的评估（例如，α-平滑肌肌动蛋白，神经元神经胶质抗原2和血小板衍生生长因子受体β）。该搜索产生了7项符合条件的研究（从2008年到2018年）。最常用于周细胞检测的标志物是α-平滑肌肌动蛋白和神经元-神经胶质抗原2。审查的研究表明，在OSCC中，未成熟血管的存在表现出周细胞覆盖率的降低，并表明抗癌疗法可能有助于血管正常化和周细胞恢复。在OSCC发展和癌症治疗期间，周细胞群体受到显着影响。虽然这些发现可能表明周细胞在OSCC进展中的作用，现有的有限数据使我们无法得出结论,它们是否改变了肿瘤微环境和临床结局.
