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Abstract：
Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol (DAG) generated in the different cellular compartments in various physiological processes. DAG accumulates in multiple organs of the obese subjects, which leads to the disruption of metabolic homeostasis and the development of diabetes as well as associated diseases. Multiple studies proved that aberrant activation of PKCs and PKDs contributes to the development of metabolic diseases. DAG-sensing PKC and PKD isoforms play a crucial role in the regulation of metabolic homeostasis and therefore might serve as targets for the treatment of metabolic disorders such as obesity and diabetes.
摘要：
蛋白激酶C（PKC）和蛋白激酶D（PKD）同种型可以感测各种生理过程中不同细胞区室中产生的二酰甘油（DAG）。DAG在肥胖受试者的多个器官中积累，这导致代谢稳态的破坏和糖尿病以及相关疾病的发展。多项研究证明，PKCs和PKDs的异常激活有助于代谢性疾病的发展。DAG敏感的PKC和PKD亚型在代谢稳态的调节中起着至关重要的作用，因此可以作为治疗肥胖和糖尿病等代谢疾病的靶标。
