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Abstract：
OBJECTIVE: To investigate olfactory dysfunction (OD) in patients with mild coronavirus disease 2019 (COVID-19) through patient-reported outcome questionnaires and objective psychophysical testing.
METHODS: COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests.
RESULTS: Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip.
CONCLUSIONS: A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.
METHODS: COVID-19 patients with self-reported sudden-onset OD were recruited. Epidemiological and clinical data were collected. Nasal complaints were evaluated with the sinonasal outcome-22. Subjective olfactory and gustatory status was evaluated with the National Health and Nutrition Examination Survey. Objective OD was evaluated using psychophysical tests.
RESULTS: Eighty-six patients completed the study. The most common symptoms were fatigue (72.9%), headache (60.0%), nasal obstruction (58.6%), and postnasal drip (48.6%). Total loss of smell was self-reported by 61.4% of patients. Objective olfactory testings identified 41 anosmic (47.7%), 12 hyposmic (14.0%), and 33 normosmic (38.3%) patients. There was no correlation between the objective test results and subjective reports of nasal obstruction or postnasal drip.
CONCLUSIONS: A significant proportion of COVID-19 patients reporting OD do not have OD on objective testing.
摘要：
目的：通过患者报告的结局问卷和客观的心理物理测试，调查2019年轻度冠状病毒病（COVID-19）患者的嗅觉功能障碍（OD）。
方法：招募自我报告突发性OD的COVID-19患者。收集流行病学和临床数据。用鼻窦结果-22评估鼻腔不适。通过国家健康和营养检查调查评估主观嗅觉和味觉状态。使用心理物理测试评估目标OD。
结果：86名患者完成了研究。最常见的症状是疲劳（72.9%），头痛（60.0%），鼻塞(58.6%),和鼻后滴漏(48.6%)。61.4％的患者自我报告了全部嗅觉丧失。客观嗅觉测试确定了41种不良症状(47.7%)，12次充血（14.0%），33例(38.3%)患者。客观测试结果与鼻塞或鼻后滴漏的主观报告之间没有相关性。
结论：报告OD的COVID-19患者中有很大一部分在客观测试中没有OD。
方法：招募自我报告突发性OD的COVID-19患者。收集流行病学和临床数据。用鼻窦结果-22评估鼻腔不适。通过国家健康和营养检查调查评估主观嗅觉和味觉状态。使用心理物理测试评估目标OD。
结果：86名患者完成了研究。最常见的症状是疲劳（72.9%），头痛（60.0%），鼻塞(58.6%),和鼻后滴漏(48.6%)。61.4％的患者自我报告了全部嗅觉丧失。客观嗅觉测试确定了41种不良症状(47.7%)，12次充血（14.0%），33例(38.3%)患者。客观测试结果与鼻塞或鼻后滴漏的主观报告之间没有相关性。
结论：报告OD的COVID-19患者中有很大一部分在客观测试中没有OD。
