Pathogenesis of Influenza A(H7N9) Virus in Aged Nonhuman Primates.

• 影响指数: 7.759
• 发表时间: 09 2020 1
• 来源期刊: J Infect Dis
• DOI: 10.1093/infdis/jiaa267
• PMID: 32433769
• 文章类型: Comparative Study
• 中科院分区: Q1
• 方向: 医学
• 作者列表: Fukuyama S,Iwatsuki-Horimoto K,Kiso M,Nakajima N,Gregg RW,Katsura H,Tomita Y,Maemura T,da Silva Lopes TJ,Watanabe T,Shoemaker JE,Hasegawa H,Yamayoshi S,Kawaoka Y

关键词: Aging; dysregulated immunity; immune senescence; influenza; nonhuman primate

Mesh: Aging; Animals; Cytokines / immunology; Disease Models, Animal; Female; Influenza A Virus, H7N9 Subtype; Lung / immunology pathology virology; Macaca fascicularis; Orthomyxoviridae Infections / immunology virology; Virus Replication

Abstract

The avian influenza A(H7N9) virus has caused high mortality rates in humans, especially in the elderly; however, little is known about the mechanistic basis for this. In the current study, we used nonhuman primates to evaluate the effect of aging on the pathogenicity of A(H7N9) virus. We observed that A(H7N9) virus infection of aged animals (defined as age 20-26 years) caused more severe symptoms than infection of young animals (defined as age 2-3 years). In aged animals, lung inflammation was weak and virus infection was sustained. Although cytokine and chemokine expression in the lungs of most aged animals was lower than that in the lungs of young animals, 1 aged animal showed severe symptoms and dysregulated proinflammatory cytokine and chemokine production. These results suggest that attenuated or dysregulated immune responses in aged animals are responsible for the severe symptoms observed among elderly patients infected with A(H7N9) virus.