PDF(Sci-hub)
Abstract：
IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γδ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT® biocurators for several veterinary species, i.e., cat (Felis catus), dog (Canis lupus familiaris), ferret (Mustela putorius furo), pig (Sus scrofa), rabbit (Oryctolagus cuniculus), rhesus monkey (Macaca mulatta), and sheep (Ovis aries). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on Homo sapiens. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.
摘要：
IMGT®,国际ImMunoGeneTics信息系统®是免疫遗传学和免疫信息学的全球参考。由Marie-PauleLefranc（蒙彼利埃大学和CNRS）于1989年创立，IMGT®标志着免疫信息学的出现，出现在免疫遗传学和生物信息学之间的界面。IMGT®专门从事免疫球蛋白(IG)或抗体，T细胞受体(TR),主要组织相容性（MH），以及IgSF和MhSF超家族的蛋白质。T细胞受体分为两组,αβ和γδTR，它们表达含有α和β的不同TR，或γ和δ链，分别。TRβ基因座（TRB）最近由IMGT®生物urators对几种兽药物种进行了描述和注释，即，猫（Feliscatus），狗（犬狼疮），雪貂（Mustelaputoriusfuro），猪（Susscrofa），兔（孔雀），恒河猴（猕猴），和绵羊（Ovisaries）。本研究的目的是比较基于智人的这些不同兽医物种之间的TRB基因座基因。结果表明，存在相似性，但也存在差异，包括亚组的基因数量，这些基因可能在进化过程中表现出重复和/或缺失。
