关键词: Basal cell carcinoma Brachytherapy Cutaneous squamous cell carcinoma Electronic brachytherapy Keratinocyte carcinoma Radiation therapy Skin cancer

Mesh : Brachytherapy / methods standards Carcinoma, Basal Cell / radiotherapy Carcinoma, Squamous Cell / radiotherapy Consensus Dose Fractionation, Radiation Humans Patient Selection Radioisotopes / therapeutic use Skin Neoplasms / radiotherapy United States

来  源:   DOI:10.1016/j.brachy.2020.04.004   PDF(Sci-hub)

Abstract:
Keratinocyte carcinoma (KC, previously nonmelanoma skin cancer) represents the most common cancer worldwide. While surgical treatment is commonly utilized, various radiation therapy techniques are available including external beam and brachytherapy. As such, the American Brachytherapy Society has created an updated consensus statement regarding the use of brachytherapy in the treatment of KCs.
Physicians and physicists with expertise in skin cancer and brachytherapy created a consensus statement for appropriate patient selection, data, dosimetry, and utilization of skin brachytherapy and techniques based on a literature search and clinical experience.
Guidelines for patient selection, evaluation, and dose/fractionation schedules to optimize outcomes for patients with KC undergoing brachytherapy are presented. Studies of electronic brachytherapy are emerging, although limited long-term data or comparative data are available. Radionuclide-based brachytherapy represents an appropriate option for patients with small KCs with multiple techniques available.
Skin brachytherapy represents a standard of care option for appropriately selected patients with KC. Radionuclide-based brachytherapy represents a well-established technique; however, the current recommendation is that electronic brachytherapy be used for KC on prospective clinical trial or registry because of a paucity of mature data.
摘要:
角质形成细胞癌(KC,以前的非黑色素瘤皮肤癌)代表了全球最常见的癌症。虽然通常使用手术治疗,各种放射治疗技术,包括外波束和近距离放射治疗。因此,美国近距离放射治疗学会就近距离放射治疗在KCs治疗中的应用发表了最新的共识声明.
具有皮肤癌和近距离放射治疗专业知识的医师和物理学家为适当的患者选择达成了共识。数据,剂量测定法,在文献检索和临床经验的基础上,利用皮肤近距离放射治疗和技术。
患者选择指南,评估,和剂量/分割时间表,以优化接受近距离放射治疗的KC患者的结局。电子近距离放射治疗的研究正在兴起,尽管可获得的长期数据或比较数据有限。基于放射性核素的近距离放射治疗是具有多种可用技术的小KC患者的适当选择。
皮肤近距离放射治疗代表了适当选择的KC患者的标准护理选择。基于放射性核素的近距离放射治疗是一种成熟的技术;然而,目前的建议是,由于缺乏成熟的数据,在前瞻性临床试验或注册中对KC使用电子近距离放射治疗.
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