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Abstract：
The present study aimed to evaluate the safety of high-intensity focused ultrasound (HIFU) treatment on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer. This trial included 15 patients with pancreatic cancer (9 females and 6 males; age, 39-81 years; median age, 62 years). All patients underwent preoperative computed tomography (CT) or magnetic resonance imaging (MRI) and color Doppler flow imaging (CDFI) to assess the vascular hemodynamics of peripancreatic arterial and venous blood vessels pre-treatment. These patients were re-examined within 1 week post-HIFU treatment. Then, vascular adverse events were observed and followed up clinically. Prior to HIFU treatment, vessel involvement was recorded in 13 patients, including tumor lesions invading 19 veins and 14 arteries, which refers to the growth of pancreatic tumor lesions surrounding blood vessels, or tumor growth into blood vessels. In addition, 9 veins and 13 arteries were <1 cm from the lesions. The hemodynamic parameters of peripancreatic vessels were measured using CDFI, including mean blood flow velocity, peak systolic blood flow velocity, vascular resistance index, vascular pulsatility index, vascular diameter, vascular blood flow and other indicators, to assess vascular perfusion in CT/MRI. There were no significant differences in preoperative and postoperative hemodynamic data (P>0.05). Overall, HIFU demonstrated no negative effects on peripancreatic arterial and venous blood vessels in patients with pancreatic cancer, even with tumor lesions wrapped in blood vessels. In addition, no complications of vascular stenosis and vascular adverse events were observed in the present study.
摘要：
本研究旨在评估高强度聚焦超声（HIFU）治疗胰腺癌患者胰腺周围动静脉血管的安全性。该试验包括15例胰腺癌患者（9例女性和6例男性；年龄，39-81岁；平均年龄，62年）。所有患者术前均行计算机断层扫描（CT）或磁共振成像（MRI）和彩色多普勒血流显像（CDFI），以评估胰周动静脉血管预处理的血管血流动力学。这些患者在HIFU治疗后1周内重新检查。然后，观察血管不良事件并进行临床随访.在HIFU治疗之前，记录了13例患者的血管受累，包括侵犯19条静脉和14条动脉的肿瘤病变,指胰腺肿瘤病变在血管周围的生长，或者肿瘤生长成血管.此外,9条静脉和13条动脉距离病变<1cm。使用CDFI测量胰周血管的血流动力学参数，包括平均血流速度,收缩期血流速度峰值,血管阻力指数，血管搏动指数,血管直径,血管血流量和其他指标，在CT/MRI中评估血管灌注。术前、术后血流动力学数据差异无统计学意义(P>0.05)。总的来说,HIFU对胰腺癌患者的胰周动脉和静脉血管没有负面影响，即使肿瘤病变包裹在血管中。此外,本研究未观察到血管狭窄并发症和血管不良事件.
