关键词: Ewing sarcoma FISH IHC fine-needle aspiration cytology lung

Mesh : 12E7 Antigen / metabolism Cyclophosphamide / therapeutic use Doxorubicin / therapeutic use Endoscopic Ultrasound-Guided Fine Needle Aspiration Humans Immunohistochemistry In Situ Hybridization, Fluorescence Lung / pathology Lung Neoplasms / diagnosis drug therapy pathology Male Middle Aged Proto-Oncogene Protein c-fli-1 / metabolism RNA-Binding Protein EWS / genetics Sarcoma, Ewing / diagnosis drug therapy pathology Vincristine / therapeutic use

来  源:   DOI:10.1002/dc.24458   PDF(Sci-hub)

Abstract:
Primary Ewing sarcoma (ES) of the lung is anecdotally rare, with few cases reported in literature. This report describes a 46 year-old man who presented with cough and chest pain. CT Thorax revealed a lesion in the right lung. Ultrasound guided fine-needle aspiration of the mass and subsequent cytologic examination exhibited a small round cell morphology. Immunohistochemistry done on the cell block revealed CD 99 and FLI-1 positivity, confirming the diagnosis of ES. FISH supported the diagnosis, showing the EWSR1 rearrangement. Radiologic investigations ruled out a primary tumour elsewhere, confirming the diagnosis of primary pulmonary ES. The patient was started on chemotherapy.
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