Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice.

抗磷酸胆碱的治疗性抗体在动脉粥样硬化小鼠中保留冠状动脉功能并减弱血管 18F - FDG 摄取。

• 影响指数: 9.531
• 发表时间: Apr 2020
• 来源期刊: JACC Basic Transl Sci
• DOI: 10.1016/j.jacbts.2020.01.008
• PMID: 32368695
• 文章类型: Journal Article
• 作者列表: Ståhle M,Silvola JMU,Hellberg S,de Vries M,Quax PHA,Kroon J,Rinne P,de Jong A,Liljenbäck H,Savisto N,Wickman A,Stroes ESG,Ylä-Herttuala S,Saukko P,Abrahamsson T,Pettersson K,Knuuti J,Roivainen A,Saraste A

关键词: 18F-FDG, 18F-fluorodeoxyglucose; 18F-fluorodeoxyglucose positron emission tomography; ANOVA, analysis of variance; ApoB, apolipoprotein-B; CFR, coronary flow reserve; HAEC, human aortic endothelial cell; ICAM, intracellular adhesion molecule; IL, interleukin; Ig, immunoglobulin; LDLR, low-density lipoprotein receptor; Lp(a), lipoprotein(a); NO, nitric oxide; OxLDL, oxidized low-density lipoprotein cholesterol; OxPLs, oxidized phospholipids; PC, phosphorylcholine; PC-mAb, human PC antibody; VCAM, vascular cell adhesion molecule; atherosclerosis; coronary flow reserve; inflammation; phosphorylcholine

Abstract

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of 18F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.

摘要

这项研究表明，在氧化磷脂上使用抗磷酸胆碱的治疗性单克隆免疫球蛋白G1抗体治疗可保留冠状动脉血流储备并减轻动脉粥样硬化炎症，这是由动脉粥样硬化小鼠摄取18F-氟代脱氧葡萄糖决定的。非侵入性成像技术代表了在临床研究中评估磷酸胆碱靶向治疗对冠状动脉功能和动脉粥样硬化的功效的转化工具。