The unsynchronized changes of CT image and nucleic acid detection in COVID-19: reports the two cases from Gansu, China.

• 发表时间: Apr 2020 22
• 来源期刊: Respir Res
• DOI: 10.1186/s12931-020-01363-7
• PMID: 32321530
• 文章类型: Case Reports
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Gao J,Liu JQ,Wen HJ,Liu H,Hu WD,Han X,Li CX,Wang XJ

关键词: COVID-19; CT image; Nucleic acid detection; SARS-CoV-2

Mesh: Adult; Betacoronavirus; COVID-19; COVID-19 Testing; China; Clinical Laboratory Techniques; Coronavirus Infections / diagnosis diagnostic imaging drug therapy; Humans; Lung / diagnostic imaging virology; Male; Pandemics; Pneumonia, Viral / diagnosis diagnostic imaging drug therapy; RNA, Viral / isolation & purification; SARS-CoV-2; Tomography, X-Ray Computed; Viral Load

Abstract

The novel coronavirus disease (COVID-19) outbreak started in December 2019 in Wuhan, China, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The CT image is used to assess the disease progress, whereas the continued two times of negative results from SARS-CoV-2 nucleic acid detection had been considered as a criterion for ending antiviral treatment. We compared the two COVID-19 cases with similar backgrounds and CT image repeated intervals under treatment. Our report highlighted the unsynchronized expression in the changes of CT image and nucleic acid detection in COVID-19, and lasting positive nucleic acid test result in patients recovered from pneumonia. It may be contributed to recognize the disease and improve prevention.