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Abstract：
Intestinal parasites affect millions of children globally. We aimed to assess effects of deworming children on nutritional and cognitive outcomes across potential effect modifiers using individual participant data (IPD). We searched multiple databases to 27 March 2018, grey literature, and other sources. We included randomised and quasi randomised trials of deworming compared to placebo or other nutritional interventions with data on baseline infection. We used a random-effects network meta-analysis with IPD and assessed overall quality, following a pre-specified protocol. We received IPD from 19 trials of STH deworming. Overall risk of bias was low. There were no statistically significant subgroup effects across age, sex, nutritional status or infection intensity for each type of STH. These analyses showed that children with moderate or heavy intensity infections, deworming for STH may increase weight gain (very low certainty). The added value of this review is an exploration of effects on growth and cognition in children with moderate to heavy infections as well as replicating prior systematic review results of small effects at the population level. Policy implications are that complementary public health strategies need to be assessed and considered to achieve growth and cognition benefits for children in helminth endemic areas.
摘要：
肠道寄生虫影响全球数百万儿童。我们旨在使用个体参与者数据（IPD）评估驱虫儿童对营养和认知结果的影响。我们搜索了多个数据库，直到2018年3月27日，灰色文献，和其他来源。我们纳入了驱虫与安慰剂或其他营养干预相比的随机和准随机试验，以及基线感染数据。我们使用随机效应网络荟萃分析与IPD和评估总体质量，遵循预先指定的协议。我们从19项STH驱虫试验中获得了IPD。总体偏倚风险较低。不同年龄的亚组效应没有统计学意义，性别,每种类型STH的营养状况或感染强度。这些分析表明，中度或重度感染的儿童，对STH进行驱虫可能会增加体重增加（确定性非常低）。这篇综述的附加值是探索对中度至重度感染儿童的生长和认知的影响，以及复制先前在人群水平上的小影响的系统综述结果。政策含义是，需要评估和考虑补充公共卫生策略，以实现蠕虫流行地区儿童的成长和认知益处。
