Thirty-eight patients with genetically confirmed hereditary TTR amyloidosis and 26 with definite CIDP according to the EFNS/PNS guidelines and negative TTR-FAP genetic testing were involved in this study. We compared the ESC for feet and hands measured by Sudoscan for each patient.
ESC (µS) was significantly lower in TTR-FAP for both hands (72 vs 45, p < 0.0001) and feet (77 vs 35, p < 0.0001). Feet ESC < 64 µS had a 89% sensitivity and a 96% specificity to differentiate between CIDP and TTR-FAP.
Sudoscan is a fast, non-invasive and easy to perform test, able to distinguish CIDP and TTR-FAP patients with good sensitivity and specificity.
Sudoscan can be helpful in distinguishing between CIDP and TTR-FAP.
本研究涉及38例遗传证实的遗传性TTR淀粉样变性患者和26例符合EFNS/PNS指南且TTR-FAP基因检测阴性的患者。我们比较了每位患者通过Sudoscan测量的脚和手的ESC。
双手(72vs45,p<0.0001)和脚(77vs35,p<0.0001)的TTR-FAPESC(µS)显着降低。FeetESC<64µS对CIDP和TTR-FAP之间的区分具有89%的灵敏度和96%的特异性。
Sudoscan是一种快速,非侵入性和易于执行的测试,能够区分CIDP和TTR-FAP患者具有良好的敏感性和特异性。
Sudoscan有助于区分CIDP和TTR-FAP。