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Abstract：
We performed a systematic review to identify and summarize the effects of distinctive aerobic exercise (AE) protocols on chronic allergic lung inflammation reported in asthma animal models. We identified 255 preclinical studies of asthma and AE protocols by comprehensive searches in PubMed, ScienceDirect and LILACS for peer-reviewed journals, using the search components \"exercise,\" \"lung inflammation,\" and \"asthma,\" without restrictions on publication date. Twenty-two studies were selected that met all eligibility criteria. Most studies used an ovalbumin experimental model and performed experiments with BALB/c mice. Most studies performed treadmill AE, using protocols of 30 to 60 minutes, 3 to 5 times/week, for 4 to 8 weeks. The results showed that the effects of AE on lungs were protocol dependent, but generaly, there was a decrease in inflammatory cell influx and Th2 cytokines, as well as an increase in anti-inflammatory defenses. However, the immunoregulation of globulins and nitric oxide levels in asthma seemed to be associated with the onset of AE. The results suggest that AE plays an important immunoregulatory role in animal models of asthma, with effects mainly mediated by increased anti-inflammatory defenses and reduced Th2 response. In parallel, prophylactic and therapeutic AE also played important roles in decreasing bronchial responsiveness and attenuating lung remodeling in animal models of asthma, secondary outcomes in this systematic review. The review protocol was published for free access in October 2017 on the Systematic Review Facility (SyRF) platform (http://syrf.org.uk/protocols/).
摘要：
我们进行了系统评价，以确定和总结独特的有氧运动（AE）方案对哮喘动物模型中报道的慢性过敏性肺部炎症的影响。我们通过在PubMed中进行全面搜索，确定了255项哮喘和AE方案的临床前研究，ScienceDirect和LILACS用于同行评审期刊，使用搜索组件“练习，肺部炎症，“和”哮喘，\"没有发布日期的限制。选择了符合所有资格标准的22项研究。大多数研究使用卵清蛋白实验模型并用BALB/c小鼠进行实验。大多数研究进行了跑步机AE，使用30到60分钟的协议，3-5次/周,4到8周。结果表明，AE对肺的影响是协议依赖性的，但一般来说,炎症细胞内流和Th2细胞因子减少，以及抗炎防御的增加。然而,哮喘中球蛋白和一氧化氮水平的免疫调节似乎与AE的发作有关.结果提示AE在哮喘动物模型中起着重要的免疫调节作用。其作用主要由增加的抗炎防御和减少的Th2反应介导。并行,在哮喘动物模型中，预防和治疗性AE在降低支气管反应性和减轻肺重塑方面也发挥了重要作用。本系统综述的次要结局。审查协议于2017年10月在系统审查设施（SyRF）平台（http://syrf.org。英国/协议/）。
