Metabolic effects of anthelminthic drugs in the larval stage of the cestode Taenia crassiceps, cysticercosis experimental model - A review.

驱虫药在头孢带虫幼虫期的代谢作用 ，囊虫病实验模型 - 综述。

• 影响指数: 3.222
• 发表时间: Jun 2020
• 来源期刊: Acta Trop
• DOI: 10.1016/j.actatropica.2020.105448
• PMID: 32194066
• 文章类型: Journal Article
• 中科院分区: Q2
• 方向: 医学
• 作者列表: Vinaud MC,Ambrosio J

关键词: Albendazole; Benzimidazole derivatives; Energy metabolism; Nitazoxanide; Praziquantel; Taenia crassiceps

Mesh: Animals; Anthelmintics / pharmacology; Cysticercosis / drug therapy; Humans; Larva / drug effects metabolism; Taenia / drug effects metabolism

Abstract

Taenia crassiceps is an experimental model used for cysticercosis studies and has suffered metabolic analyzes regarding the effect of anthelminthic drugs. The metabolic analyses are useful tools to determine the drugs mode of action and the parasite`s survival mechanisms. The energetic pathways are good candidates for this kind of approach as they are essential for the parasite`s survival and adaptation to the environment. In this review we discuss the anthelminthic drugs mode of action and its metabolic impact on Taenia crassiceps cysticerci.

摘要

头肌带虫是用于囊虫病研究的实验模型，并对驱虫药的作用进行了代谢分析。代谢分析是确定药物作用方式和寄生虫生存机制的有用工具。精力充沛的途径是这种方法的良好候选者，因为它们对于寄生虫的生存和适应环境至关重要。在这篇综述中，我们讨论了驱虫药的作用方式及其对猪带虫囊虫的代谢影响。