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Abstract：
BACKGROUND: Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) differed between cases and non-cases of OT.
METHODS: Electronic repositories; PUBMED, EMBASE and Cochrane library were explored through December 2019 to retrieve published articles for inclusion in the meta-analysis after quality assessment. Heterogeneity was assessed using I2 statistics, the effect of individual studies on the overall effect size was tested using sensitivity analysis and funnel plot was used to evaluate publication bias.
RESULTS: Twelve studies, involving 1767 OT cases and 229,167 non-cases of OT were included in this meta-analysis and I2 statistics ranged between 97 and 99%. Mean circulating TC (- 16.60 [- 32.43, - 0.77]mg/dL; P = 0.04) and HDL (- 0.25[- 0.43, - 0.08]mmol/L; P = 0.005) were significantly lower among OT cases compared to non-OT cases.
CONCLUSIONS: Decreased TC and HDL profiles were observed among subjects with OT in this collection of reports. The implications of TC and HDL in tumour manifestations and growth need to be validated in a large multi-ethnic longitudinal cohort adjusting for relevant confounders.
METHODS: Electronic repositories; PUBMED, EMBASE and Cochrane library were explored through December 2019 to retrieve published articles for inclusion in the meta-analysis after quality assessment. Heterogeneity was assessed using I2 statistics, the effect of individual studies on the overall effect size was tested using sensitivity analysis and funnel plot was used to evaluate publication bias.
RESULTS: Twelve studies, involving 1767 OT cases and 229,167 non-cases of OT were included in this meta-analysis and I2 statistics ranged between 97 and 99%. Mean circulating TC (- 16.60 [- 32.43, - 0.77]mg/dL; P = 0.04) and HDL (- 0.25[- 0.43, - 0.08]mmol/L; P = 0.005) were significantly lower among OT cases compared to non-OT cases.
CONCLUSIONS: Decreased TC and HDL profiles were observed among subjects with OT in this collection of reports. The implications of TC and HDL in tumour manifestations and growth need to be validated in a large multi-ethnic longitudinal cohort adjusting for relevant confounders.
摘要：
背景：关于脂质分布与卵巢肿瘤（OT）之间关联的一些报道的现有数据表明了不同的结论。我们的目的是检查循环血脂谱：总胆固醇（TC），甘油三酯（TG），OT病例和非病例的高密度脂蛋白（HDL）和低密度脂蛋白（LDL）不同。
方法：电子存储库；PUBMED，EMBASE和Cochrane图书馆在2019年12月进行了探索，以检索已发表的文章，以纳入质量评估后的荟萃分析。异质性使用I2统计学进行评估，使用敏感性分析检验了单项研究对总体效应大小的影响,并使用漏斗图评估发表偏倚.
结果：12项研究，本荟萃分析包括1767例OT病例和229,167例非OT病例,I2统计学介于97%至99%之间.与非OT病例相比，OT病例的平均循环TC（-16.60[-32.43，-0.77]mg/dL;P=0.04）和HDL（-0.25[-0.43，-0.08]mmol/L;P=0.005）显着降低。
结论：在本报告集合中，在患有OT的受试者中观察到TC和HDL谱降低。TC和HDL在肿瘤表现和生长中的意义需要在大型多种族纵向队列中进行验证，以适应相关的混杂因素。
方法：电子存储库；PUBMED，EMBASE和Cochrane图书馆在2019年12月进行了探索，以检索已发表的文章，以纳入质量评估后的荟萃分析。异质性使用I2统计学进行评估，使用敏感性分析检验了单项研究对总体效应大小的影响,并使用漏斗图评估发表偏倚.
结果：12项研究，本荟萃分析包括1767例OT病例和229,167例非OT病例,I2统计学介于97%至99%之间.与非OT病例相比，OT病例的平均循环TC（-16.60[-32.43，-0.77]mg/dL;P=0.04）和HDL（-0.25[-0.43，-0.08]mmol/L;P=0.005）显着降低。
结论：在本报告集合中，在患有OT的受试者中观察到TC和HDL谱降低。TC和HDL在肿瘤表现和生长中的意义需要在大型多种族纵向队列中进行验证，以适应相关的混杂因素。
