Spontaneous Coronary Artery Dissection in Females With the Fragile X FMR1 Premutation.

具有脆性 X FMR1 前突变的女性自发性冠状动脉夹层。

• 发表时间: Jan 2020
• 来源期刊: JACC Case Rep
• DOI: 10.1016/j.jaccas.2019.11.058
• PMID: 32154514
• 文章类型: Journal Article
• 作者列表: McKenzie FJ,Tassankijpanich N,Epps KC,March SK,Hagerman RJ

Abstract

This paper reports 2 cases of female carriers of the FMR1 premutation for developing spontaneous coronary artery dissection (SCAD). These women had classical presentations of premutation symptoms, including anxiety, depression, and connective tissue problems, all of which can contribute to SCAD. These cases suggest a possible connection between the fragile X premutation and a predisposition to SCAD.

摘要

本文报告2例FMR1前突变女性携带者发生自发性冠状动脉夹层(SCAD)。这些女性有典型的突变前症状，包括焦虑,抑郁症,和结缔组织问题，所有这些都可以为SCAD做出贡献。这些情况表明，脆性X前突变与SCAD易感性之间可能存在联系。