关键词: depressive disorder haematology (incl blood transfusion) nutrition and metabolism psychiatry vitamins and supplements

Mesh : Aged Anemia / etiology Ascorbic Acid / blood therapeutic use Depression / etiology Female Humans Scurvy / complications drug therapy

来  源:   DOI:10.1136/bcr-2019-233645   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
A 66-year-old Caucasian woman was admitted with deteriorating mental health in the setting of background history of schizophrenia and depression. Her husband reported that she had increasing negative thoughts and decreased motivation regarding her self-care over a few weeks with no obvious stressors. Initial laboratory tests were unremarkable except for isolated normocytic anaemia. Physical examination revealed widespread bilateral upper limb ecchymoses and lower limb petechial rash. After an extensive investigation with no definitive results to explain her clinical presentations, diagnosis of scurvy was suspected and confirmed with severely low serum vitamin C level. Her clinical symptoms improved markedly with oral supplementation, which further supported the diagnosis of scurvy. Although it is now a rare condition in developed countries, this case will remind modern medical practitioners that patients with scurvy may present with non-specific symptoms and clinical findings such as depression and anaemia.
摘要:
在精神分裂症和抑郁症的背景病史中,一名66岁的白人妇女因精神健康状况恶化而入院。她的丈夫报告说,她在几周内没有明显的压力下,对自我照顾的消极思想增加,动机下降。除了孤立的正常细胞性贫血外,最初的实验室检查并不明显。体格检查发现广泛的双侧上肢瘀斑和下肢斑疹。经过广泛的调查,没有明确的结果来解释她的临床表现,怀疑诊断为镰刀病,并证实血清维生素C水平严重偏低.口服补充剂后,她的临床症状明显改善,这进一步支持了镰刀病的诊断。尽管它现在在发达国家是罕见的情况,这个案例将提醒现代医学从业者,患有镰刀病的患者可能会出现非特异性症状和临床表现,例如抑郁和贫血。
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