PDF(Sci-hub)
Abstract：
Obesity is associated with an increased risk of several major noncommunicable diseases, and is an important public health concern globally. Dietary fat content is a major contributor to the increase in global obesity rates. Changes in dietary habits, such as the quality of fatty acids in the diet, are proposed to prevent obesity and its metabolic complications. In recent years, a number of studies have found that oleic acid (OA), the most common MUFA in daily nutrition, has protective effects against human disease. Importantly, there is emerging evidence indicating the beneficial effects of OA in regulating body weight. Accordingly, the objective of this systematic review was to investigate the effects of diets enriched in monounsaturated OA on the management and prevention of obesity, emphasizing possible mechanisms of action of OA in energy homeostasis. Searches were performed in PubMed/MEDLINE, ScienceDirect, Scopus, ProQuest, and Google Scholar databases for clinical trials that examined the effects of diets rich in OA on obesity. Of 821 full-text articles assessed, 28 clinical trials were included in the present study. According to the studies examined in this review, diets enriched in OA can influence fat balance, body weight, and possibly energy expenditure. Importantly, abdominal fat and central obesity can be reduced following consumption of high-OA-containing meals. Mechanistically, OA-rich diets can be involved in the regulation of food intake, body mass, and energy expenditure by stimulating AMP-activated protein kinase signaling. Other proposed mechanisms include the prevention of the nucleotide-binding oligomerization domain-like receptor 3/caspase-1 inflammasome pathway, the induction of oleoylethanolamide synthesis, and possibly the downregulation of stearoyl-CoA desaturase 1 activity. In summary, current findings lend support to advice not restricting consumption of OA-rich meals so as to maintain a healthy body weight.
摘要：
肥胖与几种主要非传染性疾病的风险增加有关。是全球重要的公共卫生问题。膳食脂肪含量是全球肥胖率增加的主要原因。饮食习惯的改变，比如饮食中脂肪酸的质量，建议预防肥胖及其代谢并发症。近年来,许多研究发现，油酸(OA)，日常营养中最常见的MUFA，对人类疾病有保护作用。重要的是,有新的证据表明OA在调节体重方面的有益作用。因此，本系统评价的目的是调查富含单不饱和OA的饮食对肥胖管理和预防的影响，强调OA在能量稳态中的可能作用机制。在PubMed/MEDLINE中进行搜索，ScienceDirect,Scopus,ProQuest,和谷歌学术数据库的临床试验，研究了富含OA的饮食对肥胖的影响。在评估的821篇全文中，本研究包括28项临床试验。根据这篇综述中检查的研究，富含OA的饮食可以影响脂肪平衡，体重,可能还有能量消耗。重要的是,腹部脂肪和中心性肥胖可以在食用含有高OA的膳食后减少。机械上,富含OA的饮食可以参与食物摄入的调节，体重,和通过刺激AMP激活的蛋白激酶信号传导的能量消耗。其他提出的机制包括预防核苷酸结合寡聚化结构域样受体3/caspase-1炎性体途径，油酰乙醇胺的诱导合成，并且可能下调硬脂酰辅酶A去饱和酶1的活性。总之,目前的研究结果支持不限制摄入富含OA的膳食以保持健康体重的建议。
