PDF(Sci-hub)
Abstract：
Psoriasis is a chronic inflammatory disease involving multiple organ systems and affecting approximately 2% of the world\'s population. In this guideline, we focus the discussion on systemic, nonbiologic medications for the treatment of this disease. We provide detailed discussion of efficacy and safety for the most commonly used medications, including methotrexate, cyclosporine, and acitretin, and provide recommendations to assist prescribers in initiating and managing patients on these treatments. Additionally, we discuss newer therapies, including tofacitinib and apremilast, and briefly touch on a number of other medications, including fumaric acid esters (used outside the United States) and therapies that are no longer widely used for the treatment of psoriasis (ie, hydroxyurea, leflunomide, mycophenolate mofetil, thioguanine, and tacrolimus).
摘要：
银屑病是一种涉及多器官系统的慢性炎症性疾病，影响世界约2%的人口。在本准则中,我们集中讨论系统性的，治疗这种疾病的非生物药物。我们详细讨论了最常用药物的疗效和安全性，包括甲氨蝶呤,环孢菌素,和阿西汀,并提供建议，以协助处方开始和管理这些治疗的患者。此外,我们讨论新的疗法，包括托法替尼和阿普瑞司,并简单地接触了一些其他的药物，包括富马酸酯（在美国境外使用）和不再广泛用于治疗牛皮癣的疗法（即，羟基脲,来氟米特,霉酚酸酯，硫鸟嘌呤,和他克莫司)。
