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Abstract：
There is enormous global anticipation for stem cell-based therapies that are safe and effective. Numerous pre-clinical studies present encouraging results on the therapeutic potential of different cell types including tissue derived stem cells. Emerging evidences in different fields of research suggest several cell types are safe, whereas their therapeutic application and effectiveness remain challenged. Multiple factors that influence treatment outcomes are proposed including immunocompatibility and potency, owing to variations in tissue origin, ex-vivo methodologies for preparation and handling of the cells. This communication gives an overview of literature data on the different types of cells that are potentially promising for regenerative therapy. As a case in point, the recent trends in research and development of the mesenchymal stem cells (MSCs) for cell therapy are considered in detail. MSCs can be isolated from a variety of tissues and organs in the human body including bone marrow, adipose, synovium, and perinatal tissues. However, MSC products from the different tissue sources exhibit unique or varied levels of regenerative abilities. The review finally focuses on adipose tissue-derived MSCs (ASCs), with the unique properties such as easier accessibility and abundance, excellent proliferation and differentiation capacities, low immunogenicity, immunomodulatory and many other trophic properties. The suitability and application of the ASCs, and strategies to improve the innate regenerative capacities of stem cells in general are highlighted among others.
摘要：
全球对安全有效的干细胞疗法有着巨大的期待。许多临床前研究对包括组织来源的干细胞在内的不同细胞类型的治疗潜力提出了令人鼓舞的结果。不同研究领域的新证据表明几种细胞类型是安全的，而它们的治疗应用和有效性仍然面临挑战。提出了影响治疗结果的多种因素，包括免疫相容性和效力。由于组织起源的变化，用于制备和处理细胞的离体方法。本通讯概述了有关可能用于再生治疗的不同类型细胞的文献数据。作为一个恰当的例子,详细考虑了用于细胞治疗的间充质干细胞（MSC）的研究和开发的最新趋势。MSCs可以从人体的各种组织和器官中分离，包括骨髓，脂肪,滑膜,和围产期组织。然而,来自不同组织来源的MSC产物表现出独特或不同水平的再生能力。本文最后对脂肪组织来源的MSCs(ASCs)进行了综述,具有独特的属性，如更容易获得和丰富，优秀的增殖和分化能力，低免疫原性,免疫调节和许多其他营养特性。ASC的适用性和应用，和策略，以提高先天再生能力的干细胞在一般突出。
