Abstract：
Cancer is one of the prominent global causes of death and the foremost worldwide health concern. Despite unprecedented progress in cancer chemoprevention, a vast number of cancers, however, remain an undefeatable challenge for treatment modalities. Immense therapeutic activities of puerarin contribute to its use in various health disorders. In this review, we explored the potential molecular mechanisms and targets of puerarin, proving its potential as a novel anticancer agent, for future cancer therapy and chemoprevention. Several mechanisms account for anticancer activity of puerarin which includes downregulation of NF-kB signalling pathway, mTOR signalling pathway, PI3K and BCl-2 proteins and upregulation of miR-16, caspase proteins, c- Jun N terminal kinase and extracellular signal-regulated kinase 1/2. These alterations result in inhibition of cancer cell proliferation and/or induction of apoptosis. Understanding the molecular mechanisms involved in chemotherapy and chemoprevention could aid in the more pronounced exploration of puerarin in effective cancer treatment.
摘要：
癌症是全球主要的死亡原因之一，也是全球最重要的健康问题。尽管癌症化学预防取得了前所未有的进展，大量的癌症，然而,仍然是治疗方式不可战胜的挑战。葛根素的巨大治疗活性有助于其在各种健康疾病中的应用。在这次审查中,我们探索了葛根素潜在的分子机制和靶点，证明了它作为一种新型抗癌剂的潜力，未来的癌症治疗和化学预防。葛根素抗癌活性的几种机制，包括NF-kB信号通路的下调，mTOR信号通路，PI3K和BCl-2蛋白和miR-16，caspase蛋白的上调，c-JunN末端激酶和细胞外信号调节激酶1/2。这些改变导致癌细胞增殖的抑制和/或细胞凋亡的诱导。了解化疗和化学预防中涉及的分子机制可能有助于葛根素在有效癌症治疗中的更明显探索。
