PDF(Sci-hub)
Abstract：
Operational definitions of mania are based on expert consensus rather than empirical data. The aim of this study is to identify the key domains of mania, as well as the relevance of the different signs and symptoms of this clinical construct.
A review of latent factor models studies in manic patients was performed. Before extraction, a harmonization of signs and symptoms of mania and depression was performed in order to reduce the variability between individual studies.
We identified 12 studies fulfilling the inclusion criteria and comprising 3039 subjects. Hyperactivity was the clinical item that most likely appeared in the first factor, usually covariating with other core features of mania, such as increased speech, thought disorder, and elevated mood. Depressive-anxious features and irritability-aggressive behavior constituted two other salient dimensions of mania. Altered sleep was frequently an isolated factor, while psychosis appeared related to grandiosity, lack of insight and poor judgment.
Our results confirm the multidimensional nature of mania. Hyperactivity, increased speech, and thought disorder appear as core features of the clinical construct. The mood experience could be heterogeneous, depending on the co-occurrence of euphoric (elevated mood) and dysphoric (irritability and depressive mood) emotions of varying intensity. Results are also discussed regarding their relationship with other constitutive elements of bipolar disorder, such as mixed and depressive states.
A review of latent factor models studies in manic patients was performed. Before extraction, a harmonization of signs and symptoms of mania and depression was performed in order to reduce the variability between individual studies.
We identified 12 studies fulfilling the inclusion criteria and comprising 3039 subjects. Hyperactivity was the clinical item that most likely appeared in the first factor, usually covariating with other core features of mania, such as increased speech, thought disorder, and elevated mood. Depressive-anxious features and irritability-aggressive behavior constituted two other salient dimensions of mania. Altered sleep was frequently an isolated factor, while psychosis appeared related to grandiosity, lack of insight and poor judgment.
Our results confirm the multidimensional nature of mania. Hyperactivity, increased speech, and thought disorder appear as core features of the clinical construct. The mood experience could be heterogeneous, depending on the co-occurrence of euphoric (elevated mood) and dysphoric (irritability and depressive mood) emotions of varying intensity. Results are also discussed regarding their relationship with other constitutive elements of bipolar disorder, such as mixed and depressive states.
摘要：
躁狂症的操作定义基于专家共识，而不是经验数据。本研究的目的是确定躁狂症的关键领域，以及这种临床结构的不同体征和症状的相关性。
对躁狂患者的潜在因子模型研究进行了综述。提取前,为了减少个体研究之间的差异,我们对躁狂症和抑郁症的体征和症状进行了协调.
我们确定了12项符合纳入标准的研究，包括3039名受试者。多动症是最有可能出现在第一个因素中的临床项目，通常与躁狂症的其他核心特征协变，比如增加演讲，思想障碍,和提升的情绪。抑郁-焦虑特征和易怒-攻击行为构成了躁狂症的另外两个显着的维度。睡眠改变经常是一个孤立的因素，虽然精神病似乎与傲慢有关，缺乏洞察力和判断力。
我们的结果证实了躁狂症的多维性质。多动症,增加演讲,思维障碍是临床结构的核心特征。情绪体验可能是异质的，取决于不同强度的欣快（情绪升高）和烦躁不安（易怒和抑郁情绪）情绪的同时发生。还讨论了有关其与双相情感障碍的其他构成要素的关系的结果，如混合和抑郁状态。
对躁狂患者的潜在因子模型研究进行了综述。提取前,为了减少个体研究之间的差异,我们对躁狂症和抑郁症的体征和症状进行了协调.
我们确定了12项符合纳入标准的研究，包括3039名受试者。多动症是最有可能出现在第一个因素中的临床项目，通常与躁狂症的其他核心特征协变，比如增加演讲，思想障碍,和提升的情绪。抑郁-焦虑特征和易怒-攻击行为构成了躁狂症的另外两个显着的维度。睡眠改变经常是一个孤立的因素，虽然精神病似乎与傲慢有关，缺乏洞察力和判断力。
我们的结果证实了躁狂症的多维性质。多动症,增加演讲,思维障碍是临床结构的核心特征。情绪体验可能是异质的，取决于不同强度的欣快（情绪升高）和烦躁不安（易怒和抑郁情绪）情绪的同时发生。还讨论了有关其与双相情感障碍的其他构成要素的关系的结果，如混合和抑郁状态。
