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Abstract：
An ongoing question in neuroscience is how the peripheral nervous system can repair itself following an injury or insult whereas the central nervous system has a profoundly limited ability for repair. The recent and rapid advancement of our understanding of the gene expression and corresponding biochemical profiles of Schwann cells, within the distal segments of injured peripheral nerves, has helped elucidate the potential mechanisms underlying the unique ability for these cells to enable regeneration of peripheral nerve tissue. Meanwhile, with a new understanding and appreciation for the capabilities of the peripheral nervous system, we are beginning to unlock the potential for neural regeneration and repair within the central nervous system. The aim of this review is to briefly outline the historical advancements that lead to the recent concept of utilizing peripheral nerve tissue grafts or Schwann cell culture implants to serve as repair mechanisms for the central nervous system in the clinical setting of spinal cord injury, multiple sclerosis, and neurodegenerative disorders such as Parkinson\'s disease.
摘要：
神经科学中一个持续的问题是周围神经系统如何在受伤或侮辱后自我修复，而中枢神经系统的修复能力非常有限。我们对Schwann细胞的基因表达和相应的生化谱的理解的最新和快速发展，在受伤的周围神经的远端段，有助于阐明这些细胞能够再生周围神经组织的独特能力的潜在机制。同时,对周围神经系统的能力有了新的理解和认识，我们开始释放中枢神经系统内神经再生和修复的潜力。这篇综述的目的是简要概述导致在脊髓损伤的临床环境中利用周围神经组织移植物或雪旺氏细胞培养植入物作为中枢神经系统修复机制的最新概念的历史进展。多发性硬化症,和神经退行性疾病如帕金森病。
