PDF(Sci-hub)
Abstract：
Vulvar lichen sclerosus (LS) is a chronic, inflammatory dermatosis that may lead to scarring of the vulva and sexual dysfunction. LS affects women of all ages and often goes unrecognized and underreported. Uncertainty continues to exist around its pathogenesis, histologic diagnosis, and treatment. However, there have been great advances in our understanding of autoimmunogenic targets in disease formation and progression. In addition, there has been recent investigation of potential non-steroid-based treatments, including platelet-rich plasma therapy and energy-based modalities such as the fractional CO2 laser, photodynamic therapy, and high intensity focused ultrasound. Refinement of surgical techniques for restoring vulvar anatomy and treating clitoral phimosis, introital stenosis, and vulvar granuloma fissuratum is leading to improved patient outcomes. This review summarizes current perspectives on the pathogenesis, symptomatology, diagnosis, and treatment for vulvar lichen sclerosus.
摘要：
外阴硬化性苔藓(LS)是一种慢性,可能导致外阴疤痕和性功能障碍的炎症性皮肤病。LS影响所有年龄段的女性，并且经常未被识别和低估。围绕其发病机制仍然存在不确定性，组织学诊断,和治疗。然而,我们对疾病形成和进展中自身免疫原性靶标的理解有了很大进展.此外,最近对潜在的非类固醇治疗进行了调查，包括富含血小板的血浆治疗和基于能量的模式，如分数CO2激光，光动力疗法,和高强度聚焦超声。修复外阴解剖和治疗阴蒂包茎的手术技术的改进，颅内狭窄,外阴裂隙肉芽肿改善了患者的预后.这篇综述总结了目前关于发病机制的观点，症状学，诊断,外阴硬化性苔藓的治疗.
