大规模外显子组测序研究涉及自闭症神经生物学的发育和功能变化。
关键词: autism spectrum disorder cell type cytoskeleton excitatory neurons excitatory-inhibitory balance exome sequencing genetics inhibitory neurons liability neurodevelopment
Mesh : Autistic Disorder / genetics Case-Control Studies Cell Lineage Cerebral Cortex / growth & development Cohort Studies Exome Female Gene Expression Regulation, Developmental Gene Frequency Genetic Predisposition to Disease Humans Male Mutation, Missense Neurobiology / methods Neurons / metabolism Phenotype Sex Factors Single-Cell Analysis / methods Exome Sequencing / methods
来 源:
DOI:10.1016/j.cell.2019.12.036
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