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Abstract：
Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids play important roles in many physiological and pathological processes via carbohydrate-protein interactions, including cell-cell communication, bacterial and viral infections. In particular, hypersialylation in tumors, as well as their roles in tumor growth and metastasis, have been widely described. Recent studies have indicated that the aberrant sialylation is a vital way for tumor cells to escape immune surveillance and keep malignance. In this article, we outline the present state of knowledge on the metabolic pathway of human sialic acids, the function of hypersialylation in tumors, as well as the recent labeling and analytical techniques for sialic acids. It is expected to offer a brief introduction of sialic acid metabolism and provide advanced analytical strategies in sialic acid studies.
摘要：
唾液酸,九碳酸性糖的一个子集，通常作为聚糖的末端糖存在于细胞表面的糖蛋白或糖脂上。唾液酸通过碳水化合物-蛋白质相互作用在许多生理和病理过程中发挥重要作用。包括细胞-细胞通信，细菌和病毒感染。特别是,在肿瘤中唾液酸过度，以及它们在肿瘤生长和转移中的作用，已被广泛描述。最近的研究表明，异常唾液酸化是肿瘤细胞逃避免疫监视和保持恶性的重要途径。在这篇文章中,我们概述了人类唾液酸代谢途径的知识现状，肿瘤中唾液酸过度的功能，以及最近的唾液酸标记和分析技术。预计将提供唾液酸代谢的简要介绍，并在唾液酸研究中提供先进的分析策略。
