关键词: Bim SPZ1 apoptosis chemotherapy colorectal cancer
Mesh : Animals Apoptosis / drug effects genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors / drug effects genetics metabolism Bcl-2-Like Protein 11 / genetics metabolism Biomarkers, Tumor Cell Line, Tumor Cell Proliferation / genetics Colorectal Neoplasms / drug therapy metabolism pathology Fluorouracil / pharmacology Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Heterografts / growth & development metabolism Humans Mice, Nude Mitogen-Activated Protein Kinase 1 / metabolism Mitogen-Activated Protein Kinase 3 / metabolism Neoplasms, Experimental / metabolism pathology RNA, Small Interfering Up-Regulation