关键词: Assam HIV seronegative Penicillium marneffei Renal transplant Sikkim Talaromyces marneffei

Mesh : AIDS-Related Opportunistic Infections Adult Antifungal Agents / therapeutic use Child, Preschool Communicable Diseases, Emerging Diagnosis, Differential Endemic Diseases Female Histoplasmosis / diagnosis Humans India / epidemiology Male Middle Aged Mycoses / diagnosis epidemiology pathology Neglected Diseases Talaromyces / isolation & purification pathogenicity Tertiary Care Centers Tuberculosis / diagnosis

来  源:   DOI:10.1007/s11046-019-00420-0   PDF(Sci-hub)

Abstract:
Talaromycosis is a disseminated disease caused by Talaromyces (Penicillium) marneffei, mainly seen in acquired immunodeficiency syndrome (AIDS) patients. Its distribution is restricted to southeast Asian countries; a small pocket of endemicity exists in the northeast Indian state of Manipur. Here, we present a series of five cases presenting to our tertiary care hospital, originating from non-endemic states neighboring Manipur. In addition to the geographical distinction, a variety of unique features were noted in our cases, including human immunodeficiency virus (HIV)-negative hosts, the absence of typical skin lesions, presentation as pneumonia and generalized lymphadenopathy. Our series highlights the importance of distinguishing this disease from histoplasmosis and tuberculosis, both endemic in India.
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