关键词: BTK CRBN PROTACs Pharmacokinetics Target protein degradation VHL
Mesh : Acetamides / chemical synthesis chemistry pharmacokinetics pharmacology Adaptor Proteins, Signal Transducing / chemistry metabolism Adenine / analogs & derivatives chemistry metabolism Agammaglobulinaemia Tyrosine Kinase / antagonists & inhibitors genetics metabolism B-Lymphocytes / cytology metabolism Binding Sites Cell Line Drug Design Half-Life Humans Ligands Molecular Docking Simulation Mutagenesis, Site-Directed Piperidines / chemistry metabolism Protein Structure, Tertiary Proteolysis / drug effects Ubiquitin-Protein Ligases / chemistry metabolism Von Hippel-Lindau Tumor Suppressor Protein / chemistry metabolism
来 源:
DOI:10.1016/j.bmcl.2019.126877
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