PDF(Sci-hub)
Abstract：
Lesbian, bisexual, or gay individuals (LBGs) have an increased risk for mental health problems compared to heterosexuals, but this association has sparsely been investigated for psychotic disorders. The aim of this study was: (1) to examine whether LBG sexual orientation is more prevalent in individuals with a non-affective psychotic disorder (NAPD) than in people without a psychotic disorder; and if so, (2) to explore possible mediating pathways.
Sexual orientation was assessed in the 6-year follow-up assessment of the Dutch Genetic Risk and Outcome of Psychosis study (GROUP), a case-control study with 1547 participants (582 patients with psychotic disorder, 604 siblings, and 361 controls). Binary logistic regression analyses were used to calculate the risk of patients with a psychotic disorder being LBG, compared to siblings and controls. Perceived discrimination, history of bullying, childhood trauma (CT), and sexual identity disclosure were investigated as potential mediating variables.
The proportion of individuals with LBG orientation was 6.8% in patients (n = 40), 4.3% in siblings (n = 26), and 2.5% in controls (n = 10). The age- and gender-adjusted odds ratio of LBG for patients was 1.57 (95% CI 1.08-2.27; p = 0.019), compared to siblings and controls. Discrimination, bullying, and CT all partially mediated this association.
Adverse social experiences related to sexual minority status may increase the risk for NAPD. Sexual identity, behavior, and difficulties need more attention in everyday clinical practice.
Sexual orientation was assessed in the 6-year follow-up assessment of the Dutch Genetic Risk and Outcome of Psychosis study (GROUP), a case-control study with 1547 participants (582 patients with psychotic disorder, 604 siblings, and 361 controls). Binary logistic regression analyses were used to calculate the risk of patients with a psychotic disorder being LBG, compared to siblings and controls. Perceived discrimination, history of bullying, childhood trauma (CT), and sexual identity disclosure were investigated as potential mediating variables.
The proportion of individuals with LBG orientation was 6.8% in patients (n = 40), 4.3% in siblings (n = 26), and 2.5% in controls (n = 10). The age- and gender-adjusted odds ratio of LBG for patients was 1.57 (95% CI 1.08-2.27; p = 0.019), compared to siblings and controls. Discrimination, bullying, and CT all partially mediated this association.
Adverse social experiences related to sexual minority status may increase the risk for NAPD. Sexual identity, behavior, and difficulties need more attention in everyday clinical practice.
摘要：
女同性恋,双性恋,与异性恋者相比，或同性恋者（LBG）患心理健康问题的风险增加，但是这种关联很少被调查为精神病。这项研究的目的是：（1）研究非情感性精神障碍（NAPD）患者的LBG性取向是否比没有精神病的人更普遍；如果是，(2)探索可能的中介途径。
在荷兰精神病遗传风险和结果研究（GROUP）的6年随访评估中评估了性取向，一项1547名参与者的病例对照研究(582名精神病患者，604个兄弟姐妹，和361控制）。二元logistic回归分析用于计算患有LBG的精神病患者的风险。与兄弟姐妹和对照组相比。感知到的歧视，欺凌的历史，儿童创伤（CT），将性身份披露作为潜在的中介变量进行了调查。
患者中具有LBG取向的个体比例为6.8％（n=40），兄弟姐妹中4.3%(n=26)，对照组为2.5%(n=10)。患者的年龄和性别调整后的LBG比值比为1.57（95％CI1.08-2.27；p=0.019），与兄弟姐妹和对照组相比。歧视,欺凌,和CT都部分介导了这种关联。
与性少数群体地位相关的不良社会经历可能会增加NAPD的风险。性认同,行为，在日常临床实践中需要更多的关注和困难。
在荷兰精神病遗传风险和结果研究（GROUP）的6年随访评估中评估了性取向，一项1547名参与者的病例对照研究(582名精神病患者，604个兄弟姐妹，和361控制）。二元logistic回归分析用于计算患有LBG的精神病患者的风险。与兄弟姐妹和对照组相比。感知到的歧视，欺凌的历史，儿童创伤（CT），将性身份披露作为潜在的中介变量进行了调查。
患者中具有LBG取向的个体比例为6.8％（n=40），兄弟姐妹中4.3%(n=26)，对照组为2.5%(n=10)。患者的年龄和性别调整后的LBG比值比为1.57（95％CI1.08-2.27；p=0.019），与兄弟姐妹和对照组相比。歧视,欺凌,和CT都部分介导了这种关联。
与性少数群体地位相关的不良社会经历可能会增加NAPD的风险。性认同,行为，在日常临床实践中需要更多的关注和困难。
