关键词: Donación Donation Infección Infection Solid organ transplantation Transmisión Transmission Trasplante de órgano sólido

Mesh : Communicable Diseases Consensus Humans Organ Transplantation Patient Selection Societies, Medical Spain Tissue Donors

来  源:   DOI:10.1016/j.eimc.2019.10.016   PDF(Sci-hub)

Abstract:
The immunosuppressive treatment that recipients receive from a solid organ transplantation hinders the defensive response to infection. Its transmission from the donor can cause dysfunction or loss of the graft and even death of the recipient if proper preventive measures are not established. This potential risk should be thoroughly evaluated to minimise the risk of infection transmission from donor to recipient, especially with organ transplantation from donors with infections, without increasing graft dysfunction and morbidity and mortality in the recipient. This document aims to review current knowledge about infection screening in potential donors and offer clinical and microbiological recommendations about the use of organs from donors with infection based on available scientific evidence.
摘要:
受体从实体器官移植中接受的免疫抑制治疗阻碍了对感染的防御反应。如果不采取适当的预防措施,其从供体的传播会导致移植物功能障碍或丧失,甚至导致接受者死亡。应彻底评估这种潜在风险,以最大程度地减少从供体到受体的感染传播风险。特别是来自感染供体的器官移植,而不会增加移植物功能障碍和受体的发病率和死亡率。本文件旨在回顾有关潜在供体感染筛查的最新知识,并根据现有的科学证据提供有关感染供体器官使用的临床和微生物学建议。
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