Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.

• 影响指数: 16.823
• 发表时间: 06 2020 15
• 来源期刊: Angew Chem Int Ed Engl
• DOI: 10.1002/anie.201915199
• PMID: 31859381
• 文章类型: Journal Article
• 作者列表: Dong J,Pan Y,Wang H,Yang K,Liu L,Qiao Z,Yuan YD,Peh SB,Zhang J,Shi L,Liang H,Han Y,Li X,Jiang J,Liu B,Zhao D

关键词: aggregation induced emission; coordination cages; live-cell imaging; molecular rotors; self-assembly

Mesh: Fluorescent Dyes / chemistry; HeLa Cells; Humans; Single-Cell Analysis; Stilbenes; Zirconium / chemistry

Abstract

The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.