Mesh : Aged Carcinoma in Situ / chemistry pathology Carcinoma, Endometrioid / chemistry pathology Diagnosis, Differential Endometrial Neoplasms / chemistry pathology Fallopian Tube Neoplasms / pathology Fallopian Tubes / pathology Female Humans Middle Aged PAX2 Transcription Factor / analysis Precancerous Conditions / pathology Tumor Suppressor Protein p53 / analysis beta Catenin / analysis

来  源:   DOI:10.1097/PGP.0000000000000650   PDF(Sci-hub)

Abstract:
Although serous tubal intraepithelial carcinoma has been well described in the distal fallopian tube as precancers of pelvic high-grade serous carcinoma, endometrioid precancers have drawn less attention. Recently, endometrioid precursor lesions have been identified and reported to have a specific immunophenotype (PAX2-, ALDH1+, diffuse nuclear beta-catenin), as well as an association with both uterine and ovarian endometrioid carcinomas. These have been referred to as endometrioid (or type II) secretory cell outgrowths. A subset of endometrioid secretory cell outgrowths show architectural complexity resembling hyperplasia of the endometrium and have been referred to as endometrioid tubal intraepithelial neoplasia. We report 4 cases of endometrioid tubal intraepithelial neoplasia with clinical correlation and morphologic differential diagnosis.
摘要:
暂无翻译
公众号