Meeting report and review: Immunological assays and correlates of protection for next-generation influenza vaccines.

• 影响指数: 5.606
• 发表时间: 03 2020
• 来源期刊: Influenza Other Respir Viruses
• DOI: 10.1111/irv.12706
• PMID: 31837101
• 文章类型: Journal Article
• 中科院分区: Q3
• 方向: 医学
• 作者列表: Krammer F,Weir JP,Engelhardt O,Katz JM,Cox RJ

关键词: CD4; CD8; HI; MN; NI; correlates of protection; influenza; influenza vaccine; mucosal immunity; stalk antibodies

Mesh: Animals; Antibodies, Neutralizing / blood; Antibodies, Viral / blood; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Hemagglutination Inhibition Tests; Hemagglutinin Glycoproteins, Influenza Virus / immunology; Humans; Immunity, Mucosal; Influenza A Virus, H1N1 Subtype / immunology; Influenza Vaccines / biosynthesis immunology; Influenza, Human / immunology prevention & control; Models, Animal; Neuraminidase / blood immunology; Orthomyxoviridae Infections / immunology prevention & control; Serologic Tests / methods; Vaccination

Abstract

This report summarizes the discussions and conclusions from the \"Immunological Assays and Correlates of Protection for Next-Generation Influenza Vaccines\" meeting which took place in Siena, Italy, from March 31, 2019, to April 2, 2019.
Furthermore, we review current correlates of protection against influenza virus infection and disease and their usefulness for the development of next generation broadly protective and universal influenza virus vaccines.