关键词: central polydactyly cleft hand syndactyly

来  源:   DOI:10.1055/s-0038-1669364   PDF(Sci-hub)   PDF(Pubmed)

Abstract:
Experimental studies showed that central polydactyly, syndactyly, and cleft hand might appear when the same teratogenic factor acts on embryos at the same developmental stage. These observations and some clinical cases support the concept that a common etiologic mechanism is involved in the development of these malformations. We report a clinical case that demonstrates the association previously observed in experimental studies. Here, a patient with unilateral nonsyndromic cleft hand, central polydactyly, first web syndactyly, osseous syndactyly between the ring and long fingers, and minor thumb hypoplasia was presented.
摘要:
实验研究表明,中枢多指,齐体,当相同的致畸因子作用于同一发育阶段的胚胎时,可能会出现裂口。这些观察结果和一些临床病例支持以下概念:这些畸形的发展涉及共同的病因机制。我们报告了一个临床病例,证明了先前在实验研究中观察到的关联。这里,单侧非综合征性手裂的患者,中央多指,第一个网络齐体,无名指和长手指之间的骨并肢,并出现轻微的拇指发育不全。
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