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Abstract：
To assess changes of post-occlusive reactive hyperemic response in skin microcirculation among extremely obese patients 10 days and 6 months after bariatric surgery for patients with and without hypertension.
Skin blood flow was measured using PeriFlux laser Doppler fluxmetry. Data were analyzed in the entire group and two subgroups: with and without hypertension.
Data from 88 patients (mean age 42.1 ± 11.2 years, 40.5% men) were analyzed. Six months after bariatric surgery, the time to reach peak flows had been shortened (2.4 ± 1.7 vs 2.1 ± 1.0 seconds, P < .05) and the area of hyperemia had increased (1027 ± 791 vs 1386 ± 699 AU*s, P < .05). The total power of post-occlusive reactive hyperemic after occlusion had been augmented mainly with power intensification of endothelial and myogenic origin. Post-occlusive reactive hyperemic parameters had changed mainly in the subgroup with hypertension. Variations of anthropometric parameters, metabolic characteristic, and adipokines mainly influenced on studied hyperemic flow parameters variations after the intervention in multiple regression analysis.
Cutaneous post-occlusive reactive hyperemic reactivity in time and frequency domains improved 6 months after bariatric surgery, and improvements in microvascular function were observed mainly in patients with hypertension. Variations of anthropometric parameters, metabolic characteristics, and adipokines had influence on hyperemic flow reactivity.
Skin blood flow was measured using PeriFlux laser Doppler fluxmetry. Data were analyzed in the entire group and two subgroups: with and without hypertension.
Data from 88 patients (mean age 42.1 ± 11.2 years, 40.5% men) were analyzed. Six months after bariatric surgery, the time to reach peak flows had been shortened (2.4 ± 1.7 vs 2.1 ± 1.0 seconds, P < .05) and the area of hyperemia had increased (1027 ± 791 vs 1386 ± 699 AU*s, P < .05). The total power of post-occlusive reactive hyperemic after occlusion had been augmented mainly with power intensification of endothelial and myogenic origin. Post-occlusive reactive hyperemic parameters had changed mainly in the subgroup with hypertension. Variations of anthropometric parameters, metabolic characteristic, and adipokines mainly influenced on studied hyperemic flow parameters variations after the intervention in multiple regression analysis.
Cutaneous post-occlusive reactive hyperemic reactivity in time and frequency domains improved 6 months after bariatric surgery, and improvements in microvascular function were observed mainly in patients with hypertension. Variations of anthropometric parameters, metabolic characteristics, and adipokines had influence on hyperemic flow reactivity.
摘要：
评估患有和不患有高血压的减肥手术后10天和6个月的极度肥胖患者皮肤微循环闭塞后反应性充血反应的变化。
使用PeriFlux激光多普勒通量测定法测量皮肤血流量。分析了整个组和两个亚组的数据：有和没有高血压。
来自88名患者的数据（平均年龄42.1±11.2岁，40.5%的男性）进行了分析。减肥手术六个月后，达到峰值流量的时间缩短了(2.4±1.7vs2.1±1.0秒，P<.05），充血面积增加（1027±791vs1386±699AU*s，P<0.05)。闭塞后闭塞后反应性充血的总功率主要随着内皮和肌源性起源的功率增强而增加。闭塞后反应性充血参数主要在高血压亚组中发生了变化。人体测量参数的变化，代谢特征，在多元回归分析中，脂肪因子主要影响研究的充血流量参数变化。
减重手术后6个月皮肤闭塞性反应性高反应性时域和频域改善，微血管功能的改善主要见于高血压患者。人体测量参数的变化，代谢特征，脂肪因子对高血血流反应性也有影响。
使用PeriFlux激光多普勒通量测定法测量皮肤血流量。分析了整个组和两个亚组的数据：有和没有高血压。
来自88名患者的数据（平均年龄42.1±11.2岁，40.5%的男性）进行了分析。减肥手术六个月后，达到峰值流量的时间缩短了(2.4±1.7vs2.1±1.0秒，P<.05），充血面积增加（1027±791vs1386±699AU*s，P<0.05)。闭塞后闭塞后反应性充血的总功率主要随着内皮和肌源性起源的功率增强而增加。闭塞后反应性充血参数主要在高血压亚组中发生了变化。人体测量参数的变化，代谢特征，在多元回归分析中，脂肪因子主要影响研究的充血流量参数变化。
减重手术后6个月皮肤闭塞性反应性高反应性时域和频域改善，微血管功能的改善主要见于高血压患者。人体测量参数的变化，代谢特征，脂肪因子对高血血流反应性也有影响。
