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Abstract：
We present a case of spontaneous undifferentiated/unclassified sarcoma, of a pleomorphic subtype formerly known as malignant fibrous histiocytoma (UPS/MFH), arising from the pancreas of a laboratory rat. The mass was excised after laparotomy from a 6-month-old female laboratory Wistar rat. It presented a giant multilobulated mass of irregular shape, which had arisen from the pancreas and occupied almost the entire peritoneal cavity. Histologically the tumor was characterized by a highly variable morphological pattern, with frequent transitions from storiform to pleomorphic areas. An extensive immunohistochemical examination revealed no specific lines of differentiation. Immunohistochemical positivity was observed only to MIB-1 (high Ki-67 proliferation index), vimentin and CD68 antibodies. The diagnosis was compatible with UPS/MFH. To the best of our knowledge, the present case is the first report of a spontaneous primary UPS/MFH arising from the pancreas of a laboratory rat.
摘要：
我们介绍一例自发性未分化/未分类肉瘤，以前称为恶性纤维组织细胞瘤（UPS/MFH）的多形性亚型，来自实验室老鼠的胰腺。剖腹手术后从6个月大的雌性实验室Wistar大鼠中切除肿块。它呈现出一个不规则形状的巨大的多叶团块，它来自胰腺，几乎占据了整个腹膜腔。在组织学上，肿瘤的特征是高度可变的形态学模式，频繁地从矩形区域过渡到多形区。广泛的免疫组织化学检查显示没有特定的分化线。免疫组织化学阳性仅观察到MIB-1（高Ki-67增殖指数），波形蛋白和CD68抗体。诊断与UPS/MFH兼容。据我们所知,本病例是首次报道来自实验室大鼠胰腺的自发性原发性UPS/MFH。
