PDF(Sci-hub)
Abstract：
Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus. However, in several cancers, nucleolin is highly expressed both intracellularly and on the cell surface. So, it is considered as a potential target for the diagnosis and cancer therapy. Targeting nucleolin by compounds such as AS1411 aptamer can reduce tumor cell growth. In this regard, interest has increased in nucleolin as a molecular target for overcoming cancer therapy challenges. This review paper addressed recent progresses in nucleolin targeting by the G-rich AS1411 aptamer in the field of cancer therapy mainly over the past three years.
摘要：
核仁素或C23是核仁中最丰富的非核糖体磷蛋白之一。然而,在几种癌症中，核仁素在细胞内和细胞表面高度表达。所以,它被认为是诊断和癌症治疗的潜在靶点。通过化合物如AS1411适体靶向核仁素可以减少肿瘤细胞生长。在这方面,人们越来越关注核仁素作为克服癌症治疗挑战的分子靶标。本文主要综述了近三年来富含G的AS1411适体靶向核仁素在癌症治疗领域的最新进展。
