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Abstract：
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using key characteristics (KCs), we have developed ten KCs of EDCs based on our knowledge of hormone actions and EDC effects. In this Expert Consensus Statement, we describe the logic by which these KCs are identified and the assays that could be used to assess several of these KCs. We reflect on how these ten KCs can be used to identify, organize and utilize mechanistic data when evaluating chemicals as EDCs, and we use diethylstilbestrol, bisphenol A and perchlorate as examples to illustrate this approach.
摘要：
内分泌干扰化学物质（EDCs）是干扰激素作用的外源性化学物质，从而增加不良健康结果的风险，包括癌症,生殖损害，认知缺陷和肥胖。复杂的机械研究文献为EDC暴露的危害提供了证据，然而,目前尚无广泛接受的系统方法来整合这些数据以帮助识别EDC危害.受使用关键特征(KCs)改进致癌物危害识别的工作的启发，根据我们对激素作用和EDC效应的了解，我们已经开发了10个EDCKC。在这份专家共识声明中，我们描述了识别这些KC的逻辑以及可用于评估这些KC中的几种的测定法。我们反思如何使用这十个KC来识别，在评估化学品作为EDC时，组织和利用机械数据，我们用己烯雌酚,双酚A和高氯酸盐作为例子来说明这种方法。
