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Abstract：
The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment.
摘要：
研究了用50kGyγ射线（HKC）辐照的高山红景天提取物对良性前列腺增生（BPH）的影响。7周龄雄性SD大鼠皮下注射20mg/kg丙酸睾酮(TP)诱导BPH。然后，只有睾酮的组接受了睾酮，睾酮+非那雄胺组接受睾酮和非那雄胺（5mg/kg），睾酮+HKC组接受睾酮和HKC提取物(500mg/kg).测定血清或前列腺组织中的前列腺重量和二氢睾酮(DHT)水平。还测量了前列腺组织中5-α还原酶（AR）的mRNA表达。与对照组相比,TP组的前列腺重量显著改善,HKC和非那雄胺治疗组的前列腺重量降低.此外，在HKC和非那雄胺治疗组中,前列腺中5-AR的mRNA表达显著降低.同样，α-平滑肌肌动蛋白（α-SMA）和细胞角蛋白的表达水平，在HKC和非那雄胺组中与前列腺增大有关，远低于TP组。HKC治疗对睾酮诱导的BPH大鼠的疗效与非那雄胺治疗相似。HKC可能被开发为BPH治疗的潜在新药。
